Innovative Drug Discovery and Nanotechnology (Track)
Preparation And Evaluation Of Nanostructured Polymeric Materials As Vectorization Systems Of Babassu Oil
Valeria Pereira de Sousa Department of Pharmaceutics
Federal University of Rio de Janeiro
Brazil
Abstract:
Nowadays nanotechnology is very attractive for pharmaceutical industry. In this study, it was investigated the incorporation of the babassu, Orbignya speciosa extract, active against cell lines of prostatic hyperplasia, in polymer-silicate nanocomposites and PLGA nanoparticles, aiming at the preparation of nanostructured drug delivery system. The babassu nuts were peeled, ground and extracted in ethanol by shoxlhet. Nanocomposites babassu-PVPK30-Viscogel B8 were prepared by exfoliation-adsorption. The PLGA nanoparticles were obtained mixing 0.5% Pluronic solution and acetone mixture of babassu oil and PLGA. The characterization of nanosystems was performed by XRD, TGA, DLS and FTIR. The content of babassu oil and the drug release in dissolution studies were determined by GC-MS. The babassu incorporation yields obtained in all tests were above 90%. The size distribution was less than 300 nm in all cases with low polydispersity index. The XRD analysis showed not only the formation of a nanocomposite, as well as the increase in the interlayer space, indicating the intercalation of oil. Thus, the use of lamellar silicate and PLGA were an excellent alternative to obtain pharmacologically active vegetable oils nanosystems.
